Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases
نویسندگان
چکیده
منابع مشابه
Systematic discovery of linear binding motifs targeting an ancient protein interaction surface on MAP kinases
Mitogen-activated protein kinases (MAPK) are broadly used regulators of cellular signaling. However, how these enzymes can be involved in such a broad spectrum of physiological functions is not understood. Systematic discovery of MAPK networks both experimentally and in silico has been hindered because MAPKs bind to other proteins with low affinity and mostly in less-characterized disordered re...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2015
ISSN: 1744-4292,1744-4292
DOI: 10.15252/msb.20156269